Endocrine Abstracts

Introduction: Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine which is associated with obesity, insulin resistance and cardiovascular disease. It is supposed that insulin has anti-inflammatory action. The aim of the present study was to estimate serum IL-18 concentration in young healthy population, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation.Methods: We studied 36 h...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of ...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism. Material and methods: We treated 950 patients, aged 30–70 years; 87% of them were female and 13% male; 320 patients with multinodular goitre (MNG), and 630 patients with autonomous nodule (ATN). Some of the patients were treated with antithyroid drugs for 1 to...

Introduction: Ectopic release of ACTH caused by pheochromocytoma is extremely rare. The clinical picture of hypercortisolism is overlapped by catecholamine excess that makes diagnosis more difficult.Case report: A 74-year-old women was admitted to the hospital because of hypertension, recently diagnosed diabetes and weight loss (10 kg per six months). In physical examination: cachexia, dehydratation, pallor, hirsutism, proximal muscle weakness, elevated ...

Introduction: Assessment of the RAAS has been recently granted a much greater role in the evaluation of patients with arterial hypertension (AH). There is no single test efficient in selection of patients for second-step etiological investigation.Methods: 198 consecutive patients- 119 women (60%) and 79 men (40%)- hospitalized in years 2009-2011 at the Clinical Department of Endocrinology UMB as to diagnose PA. In each patient PRA and PAC (basic and afte...

Apoptosis plays a pivotal role in the regulation of the immune mechanisms in the pathogenesis of autoimmune thyroid diseases. The aim of the study was to compare soluble Fas, FasL and Bcl-2 in Graves’ disease (GD) and Hashimoto thyroiditis (HT) in relation to the age of the studied patients. The study was carried out in 5 groups of subjects: 1/14 patients with GD in euthyreosis on methimazol (euGD) 2/20 patients with hyperthyroid GD (hrGD) 3/15 patients with HT in euthyre...

Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this...

Introduction: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control in central nervous system. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells to...

Introduction: It has been recently suggested the genetic predisposition to obesity leads to increased risk of type 2 diabetes by its obesity predisposing effect. Surprisingly genetic loci that contribute to the development of obesity identified by genome-wide association studies (GWAS) account for only 2% of the variance in BMI. Visceral fat accumulation has an important role in increasing the risk of developing metabolic disorders, such as type 2 diabetes, dyslipidemia and CV...

Subclinical hyperthyroidism (SH) is characterised by supressed serum TSH concentration accompanied by fT3 and fT4 levels maintained within their reference ranges. The vascular endothelium as a specific target of thyroid hormones is strongly affected in hyperthyroidism. We aimed to compare the alterations of the endothelial function, haemostatic and inflammatory parameters in patients with SH in comparison with overt hyperthyroidism (OH) due to Graves’ disease and toxic no...